Předmět Molecular Ecology (KZO / 412I)

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Materiál	Typ	Datum	Počet stažení

Obsah

Content of lectures:Introduction to Molecular Ecology: questions and problems studied by Molecular Ecology. Population structure, speciation, reproductive strategies (inbreeding, sex ratio), demography (population expansion, bottlenecks).Molecular markers and methods of their analysis. Characterization, availability and informative value of various types of molecular markers (DNA sequences, nuclear vs. mitochondrial/plastid DNA, coding vs. non-coding DNA, microsatellites, AFLP, SNP). Analytic procedures vs. simulations (MCMC).Introduction to population and evolutionary genetics. Intraspecific genetic and phenotypic variability, Hardy-Weinberg equilibrium, neutral theory, genetic drift, molecular clock. Measures of genetic variability within and among populations, metapopulations.Genealogy vs. phylogeny. Population splitting and genetic diversification, coalescent theory, ancestral polymorphism, concerted evolution, hybridization.Demographic history. Effective population size, expansions, bottlenecks, migration. Kin selection. Reproductive strategies: sex ratio, mating system, inbreeding, social and brood parasites.Speciation, phylogeography, coevolution. Speciation process, delimitation of species, geographic distribution and methods of phylogeographic analysis. Genetic diversity mediated by geographic distance, nested clade analysis. Coevolution.Genome scan. Identification of loci under balancing/diversifying selection. Quantitative trait loci. Ecology-mediated changes in genomes (degeneration, horizontal transfer of genes).Applied aspects of molecular ecology: Study of biodiversity, barcoding, molecular ecology and conservation biology, molecular microbiology and epidemiology.New methods and programs in molecular ecology.Content of practices:Practical course on using phylogenetic and population genetic software for solving ecology and evolutionary problems.

Literatura

Beebee T., Rowe G.: Molecular evolution. Oxford university press, 2005. Christansen FB. : Theories of population variation in genes and genomes. Princeton uni. press, 2008. Mayhew P.: Discovering evolutionary ecology. Oxford university press, 2006. Templeton A.: Population genetics and microevolutionary theory. Wiley-Liss, 2006.

Požadavky

Periodicity: each academic year.

Garant

prof. RNDr. Václav Hypša, CSc.

Vyučující

prof. RNDr. Václav Hypša, CSc.prof. RNDr. Václav Hypša, CSc.