Předmět NMR Spectroscopy of Biomolecules (C6770)
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Další informace
Cíl
The course will provide introduction to modern NMR techniques which can be applied to extract structural information for small and mid-size biological macromolecules - peptides, proteins, DNA and RNA oligonucleotides. Experimental procedures and computational protocols for determination of three-dimensional structures and dynamics based on NMR data will be discussed. Students who finish the course successfully will understand principles of NMR and its applications to biochemical problems described in original research articles, to analyze NMR experiments and design their modification, to chose the correct approach of solving a given problem, and to combine results of individual approaches to obtain a complex picture of the studied problem. The course is designed so that students who continue to study in a PhD program will be able to apply the learned skills in their own research projects.
Osnova
1. NMR as a tool for structure biology2. Basic NMR Experiments3. Key to biomolecular NMR: Idea of correlation4. First step in NMR of proteins5. Second step in determination of protein structure6. From spectra to structure7. Special features of nucleic acid NMR8. Nucleic acid structure by NMR9. Molecules are not rigid10. From relaxation to molecular motions11. Molecules are not alone12. Beyond small soluble biomolecules
Literatura
Protein NMR spectroscopy :principles and practice. Edited by John Cavanagh. 2nd ed. Amsterdam: Elsevier, 2007. xxv, 885 s. ISBN 978-0-12-164491-8. info
Požadavky
The course is offered to students interested in NMR methods applied to biomacromolecules. Basic knowledge of structure of proteins and nucleic acids is expected.
Garant
doc. Mgr. Lukáš Žídek, Ph.D.
Vyučující
doc. Mgr. Lukáš Žídek, Ph.D.doc. RNDr. Radovan Fiala, CSc.