Předmět Genetic codes (C8560)

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Materiál	Typ	Datum	Počet stažení

Cíl

Main outcomes of the course include:Students will learn about different kinds of codes carried by DNA sequence;Students will gain understanding principles of different periodical codes hidden in DNA sequence; Special attention will be paid tothe understanding of principles of DNA-directed nucleosome positioning

Osnova

In addition to protein-coding message the nucleotide sequences carry instructions for DNA folding, transcription, translation framing, gene splicing, fast adaptation code, and many more (1, 2). Every sequence element belongs simultaneously to several different messages superimposed on one another. The codes of protein sequences are of this nature as well. Most prominent examples of the code overlapping and interaction will be considered. The course is based largely on the most recent publications. This includes the latest developments on the chromatin code and its interactions with other codes (3, 4). Ref. (2) is an extended summary of the course.References:1. Trifonov, E. N., Sequence codes. In: "Encyclopedia of Molecular Biology", T. E. Creighton, Ed., John Wiley & Sons, Inc., New York, 1999, p. 2324-2326.2. Trifonov, E. N., Codes of biosequences. In: The Codes of Life. The Rules of Macroevolution. Barbieri, M. (ed.). Springer. New York, in press.3. Trifonov, E. N., Kogan, S., Cohanim, A. B. Latest on the nucleosome positioning sequence patterns. In "DNA Structure, Chromatin and Gene Expression" (Eds. R. Kiyama, M. Shimizu), Transworld Research Network, Trivandrum (India), pp 43-54 (2006).4. F. Salih, B. Salih, E. N. Trifonov, Sequence-directed mapping of nucleosome positions, JBSD 26, 1-8 (2008).Outline:Periodical and aperiodical codes in DNADNA bending versus DNA curvatureNucleosome positioning - DNA sequence patternsOther codes in DNA and RNA sequences

Literatura

2. Trifonov, E. N., Codes of biosequences. In: The Codes of Life. The Rules of Macroevolution. Barbieri, M. (ed.). Springer. New York, in press.TRIFONOV, Eduard . Vocabulary of Definitions of Life Suggests a Definition. Journal of Biomolecular Structure & Dynamics, Adenine Press, 2011, roč. 29, č. 2, s. 259-266. ISSN 0739-1102. URL infoTRIFONOV, Eduard . Nucleosome Positioning by Sequence, State of the Art and Apparent Finale. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, United States: ADENINE PRESS, 2010, roč. 27, č. 6, s. 741-746. ISSN 0739-1102. infoGABDANK, Idan, Danny BARASH a Eduard TRIFONOV . Single-base Resolution Nucleosome Mapping on DNA Sequences. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, United States: ADENINE PRESS, 2010, roč. 28, č. 1, s. 107-121. ISSN 0739-1102. infoSALIH, F., B. SALIH a Eduard TRIFONOV . Sequence Structure of Hidden 10.4 base Repeat in the Nucleosomes of C.elegans. Journal of Biomolecular Structure & Dynamics, USA: Adenine Press, 2008, roč. 26, č. 3, s. 1-8. ISSN 0739-1102. infoFAJKUS, Jiří a Edward N. TRIFONOV . Columnar Packing of Telomeric Nucleosomes. Biochemical and Biophysical Research Communications, California: Academic Press, 2001, roč. 280, č. 4, s. 961-963. ISSN 0006-291X. info

Požadavky

Basic knowledge of molecular biology.

Garant

prof. RNDr. Jiří Fajkus, CSc.

Vyučující

prof. Ing. Eduard Nikolajevič Trifonov, Ph.D.prof. RNDr. Jiří Fajkus, CSc.