Předmět Early Molecular Evolution (C8570)

Na serveru studentino.cz naleznete nejrůznější studijní materiály: zápisky z přednášek nebo cvičení, vzorové testy, seminární práce, domácí úkoly a další z předmětu C8570 - Early Molecular Evolution, Přírodovědecká fakulta, Masarykova univerzita (MU).

Materiál	Typ	Datum	Počet stažení

Cíl

At the end of the course, the students will be able to:Understand evolutionary chart of codons;Understand the theory of omnipresent protein sequence motifs;Understand standard structural modules of modern proteins;Understand construction of protein sequence space.

Osnova

Four fundamentally novel, recent developments make a basis for the Theory of Early Molecular Evolution. The theory outlines the molecular events from the onset of the triplet code to the formation of the earliest sequence/structure/function modules of proteins. These developments are:1) Reconstruction of the evolutionary chart of codons (1, 2);2) Discovery of omnipresent protein sequence motifs, conserved since the last common ancestor (3, 4);3) Discovery of closed loops - standard structural modules of modern proteins (5-7);4) Construction of protein sequence space of module size fragments,with evolutionary implications (8, 9).The theory generates numerous predictions, confirmed by massive nucleotide and protein sequence analyses, such as existence of two distinct classes of amino acids, and their periodical distribution along the sequences . The emerging picture of the earliest molecular evolutionary events is outlined - consecutive engagement of codons, formation of the earliest short peptides, and growth of the polypeptide chains to the size of loop closure, 25-30 residues. Repertoire of the very first protein activities is outlined. The earliest closed loop modules are found to be associated with ATP synthesis and utilization. Ref. (10) is an extended summary of the course.1. Trifonov, E. N., Gene 261, 139-151 (2000)2. Trifonov, E. N., J Biomol Str Dyn 22, 1-11 (2004)3. Sobolevsky, Y., Trifonov, E. N., J Mol Evol 61, 591-596 (2005)4. Sobolevsky, Y., Trifonov, E. N., J Mol Evol 63, 622-634 (2006)5. Berezovsky, I. N., Grosberg, A. Y., Trifonov, E. N., FEBS Letters 466, 283-286 (2000)6. Berezovsky, I. N., Protein Engineering 16, 161-167 (2003)7. Berezovsky, I. N., Kirzhner, A., Kirzhner, V. M., Trifonov, E. N., J. Biomol Str Dyn. 21, 327-339 (2003)8. Frenkel, Z. M., Trifonov, E. N., J Theor Biol 244, 77-80 (2007)9. Frenkel, Z. M., Trifonov, E. N., Proteins Str Function Bioinf, in press10. Trifonov, E. N., Early molecular evolution, Isr J Ecol Evol in press1) Reconstruction of the evolutionary chart of codons (1, 2);2) Discovery of omnipresent protein sequence motifs, conserved since the last common ancestor (3, 4);3) Discovery of closed loops - standard structural modules of modern proteins (5-7);4) Construction of protein sequence space of module size fragments,with evolutionary implications (8, 9).

Literatura

3. Sobolevsky, Y., Trifonov, E. N., J Mol Evol 61, 591-596 (2005)8. Frenkel, Z. M., Trifonov, E. N., J Theor Biol 244, 77-80 (2007)TRIFONOV, Eduard Nikolajevič a Zakharia M FRENKEL. Origin and evolution of genes and genomes. Crucial role of triplet expansions. J. Biomol. Struct. Dynamics 12, Philadelphia: Taylor&Francis Inc., 2012, roč. 30, č. 2, s. 201-210. ISSN 0739-1102. doi:10.1080/07391102.2012.677771. URL infoPINO, Samanta, Eduard TRIFONOV a Di Ernesto MAURO. On the Observable Transition to Living Matter. Genomics, Proteomics & Bioinformatics, Elsevier Ltd., 2011, roč. 9, 1-2, s. 7-14. ISSN 1672-0229. doi:10.1016/S1672-0229(11)60002-8. infoKOREN, Zohar a Eduard TRIFONOV . Role of Everlasting Triplet Expansions in Protein Evolution. JOURNAL OF MOLECULAR EVOLUTION, New York: Springer, 2011, roč. 72, č. 2, s. 232-239. ISSN 0022-2844. doi:10.1007/s00239-010-9425-0. infoTRIFONOV, Edward a Zakharia FRENKEL. Evolution of protein modularity. Current Opinion in Structural Biology, London: Elsevier Science Ltd., 2009, roč. 19, č. 3, s. 335-340. ISSN 0959-440X. infoTRIFONOV, Edward . The origin of the genetic code and of the earliest oligopeptides. Research in Microbiology, Netherlands: Elsevier Science BV, 2009, roč. 160, č. 7, s. 481-486. ISSN 0923-2508. info

Požadavky

Basic knowledge of molecular biology.

Garant

prof. RNDr. Jiří Fajkus, CSc.

Vyučující

prof. Ing. Eduard Nikolajevič Trifonov, Ph.D.prof. RNDr. Jiří Fajkus, CSc.