Předmět Lékařská biologie I (DA0102337)
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Další informace
Sylabus
MEDICAL BIOLOGY I.first year, summer term History of biology, the central dogma Darwin, Mendel, misuse of genetics, Griffith, Avery, Watson, Crick, the central dogma Genetic code, gene structure and expression flow of genetic information, genetic code genes and expression, regulation Mutations and DNA repair mutation and polymorphism, types of mutations, types of reparations Chromatin structure structure of chromosome, types of chromosomes, human chromosomes, sex determination Eukaryotic cell differences between prokaryotic and eukaryotic cell, characteristics of eukaryotes Prokaryota and viruses archebacteria, eubacteria, reproduction of bacteria, recombination, basic structure of viruses, viral nucleic acids, viruses and transposons Cell cycle and its regulation cyclins, cyclin-dependent kinases, regulation in prokaryotes and multicellular eukaryotes, cultivation of cells Basic laws and modes of heredity Mendel laws, monogenic inheritance, mosaicism, genomic imprinting Dihybridism and gene interactions mitochondrial inheritance, dihybridism, interaction of non-allelic genes, multifactorial inheritance Gene linkage gene mapping, crossing over, recombination, gene linkage phase, linkage analysis and its use in medicine Population genetics 1 definitions, genetic variability the Hardy-Weinberg law and its use Population genetics 2 evolutionary factors and their impact, non-random mating, mutation, selection, gene drift, gene flow (migration) Clinical genetics genetic counselling: indication, methods, screening in pregnancy, prenatal diagnosis
Literatura
Presentations from lectures, practicals and seminars(available on MOODLE)Pritchard, D.: Medical genetics at a glance.Blackwell publishing, 2003 (B)+Passarge, E.: Color atlas of genetics.Thieme Verlag, 2001, 2007 (B)+Mange, E. J.: Basic human genetics.Sinauer associates Inc, 1999
Garant
prof. Ing. Zdeněk Sedláček, DrSc.