Předmět Patologie (DA0105439)

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Materiál	Typ	Datum	Počet stažení

Sylabus

Pathology - International students, 3rd year - winter semesterSchedule for group No. 1:Week Day - Time Type Content1. Mo 11:15 - 13:50 Practical training 8.00 Blue Building 2A: How the courses are organized; biohazard, personal protection (for groups 1+2)Autopsy demonstrations: Cadaverous changes: physical and chemical, autolysisprim. MUDr. D. Kodetová , as. MUDr. M. GregaÚPMM 2A a budova 11Th 11:00 - 13:35 Lecture 1. Anatomical pathology as a specialty: from historical aspects to what pathology brings to contemporary medicine: autopsy, surgical specimens, biopsy, frozen section diagnosis its importance and risks2. Laboratory methods utilized by anatomic pathology:a) classical staining methods - HE, PAS, trichrome, impregnations, elastic fibers;b) histochemistry - significance, basic reactions - non-specific esterase,chloroacetate-esterase, phosphatasesc) immunohistochemistry and in situ hybridization - principles, practical usage in diagnostic processd) electron microscopy - its usefulness and limitations3. Cell injury:a) definition, causesb) mechanisms - hypoxic and ischemic free radicalsc) cell death - apoptosis versus necrosisd) ganreneas. MUDr. M. Chadimovámalá posluchárna2. Mo 11:15 - 13:50 Practical training 8.00 Blue Building 2A: How the courses are organized; biohazard, personal protectionAutopsy demonstrations: Cadaverous changes: physical and chemical, autolysisGross and microscopic specimens: necrosis, gangrene, atrophyprim. MUDr. D. Kodetová, as. MUDr. M. GregaÚPMM 2A a budova 11Th 11:00 - 13:35 Lecture 1. Disorders of the vascular flow:a) underlying causes - diseases of the heart and of the vesselsb) venostasis acute, chronicc) pathology of shockd) hypertension - classification, pathology, complications2. Hemorrhagic diathesis:a) types of hemorrhageb) thrombocytopeniac) coagulative disorders, hereditary, DICd) vascular causesprof. MUDr. R. Kodet, CSc.malá posluchárna3. Mo 11:15 - 13:50 Practical training Autopsy demonstrations.Gross and microscopic pathology:a) disorders of the vascular flow in generalb) thrombosis, embolismas. MUDr. V. Campr, as. MUDr. J. SoukupÚPMM 2A a budova 11Th 11:00 - 13:35 Lecture Metabolic disorders of lipids, proteins and carbohydrates. Intracellular accumulations:a) steatosis, classification, forms, development inborn errors of lipid metabolism - Gaucher´s disease, Nieman-Pick´s disease, Tay-Sachs´ diseaseb) pathology of the interstitial matrix - acquired (aging, myxedema), congenital (cystic medionecrosis) and inborn errors of metabolism of proteoglycans (mucopolysacharidoses)c) glycogen storage diseases - acquired, inherited (von Gierke, Pompe)d) amyloidosisdoc. MUDr. J. Zámečník, Ph.D.malá posluchárna4. Mo 11:15 - 13:50 Practical training Autopsy demonstrations.Gross and microscopic pathology: metabolic disorders (steatosis, amyloidosis)as. MUDr. Š. Cipro, as. MUDr. J. HáčekÚPMM 2A a budova 11Th 11:00 - 13:35 Lecture Pigments and pathology of their distribution:a) autogenous - melanin, lipofuscin, ceroid, lipochrome;b) hematogenous - hemosiderin, hematoidin, hemoglobin, hematin; pathology of icterus c) exogenous - how the pigments get into the organism pneumoconiosis (anthracosis, silicosis, siderosis, asbestosis, berylliosis)sequelae of complicated pneumoconiosisdoc. MUDr. J. Zámečník, Ph.D.malá posluchárna5. Mo 11:15 - 13:50 Practical training Monday - STATE HOLIDAYtuition falls offÚPMM 2A a budova 11Th 11:00 - 13:35 Lecture Inflammation I. Non-specific inflammation:a) definition of inflammation, clinical and pathologic features - local, generalb) exudation of inflammatory cells, chemotaxis, mediatorsc) acute inflammation versus chronic inflammationd) types of exudative inflammation (serous, suppurative, lymphocytic, fibrinous, gangrenous),progression, healing, complicationsprof. MUDr. R. Kodet, CSc.malá posluchárna6. Mo 11:15 - 13:50 Practical training Autopsy demonstrations.Gross and microscopic pathology:a) calcification - dystrophic metastaticb) stones, their occurrence (gallbladder, urinary bladder, salivary glands, pancreas), pathogenesis, composition, principles of complicationsc) pathology of the pigmentsdoc. MUDr. J. Zámečník, Ph.D., as. MUDr. P. ŠkapaÚPMM 2A a budova 11Th 11:00 - 13:35 Lecture Inflammation II. Specific, granulomatous inflammation:a) definition, morphology, pathogenesisb) tuberculosis - development, progression, healingc) syphilis, leprosyd) non-caseating granulomas with a suppurative component (cat scratch disease, tularemia, brucellosis etc.)prof. MUDr. R. Kodet, CSc.malá posluchárna7. Mo 11:15 - 13:50 Practical training Autopsy demonstrations.Gross and microscopic pathology:tuberculosis and other inflammatory granulomatous diseasesas. MUDr. J. Soukup, as. MUDr. J. HáčekÚPMM 2A a budova 11Th 11:00 - 13:35 Lecture Morphology of infectious diseases I.1. General remarks:a) local spread of infectionsb) bacteriemia, sepsis, septicopyemia and its typesc) mechanisms of bacteria-induced injury, bacterial adhesins, toxins2. Common bacterial diseases:a) streptococcal and staphylococcal, meningococcal infections and their morphologyb) colibacillary infections; salmonellosis; typhus; hemophilus, pseudomonasas. MUDr. M. Chadimovámalá posluchárna8. Mo 11:15 - 13:50 Practical training Autopsy demonstrations.Gross and microscopic pathology:inflammation, non specific and specific types - repetition; infectious diseasesas. MUDr. J. Soukup, doc. MUDr. J. Zámečník, Ph.D.ÚPMM 2A a budova 11Th 11:00 - 13:35 Lecture Morphology of infectious diseases II.1. Infections caused by chlamydia, rickettsia and mycoplasma.2. Mechanisms of virus-induced injury.3. Most common infections caused by viruses - herpes, varicella-zoster, CMV, EBV; influenza, measles, rubella.4. Morphology of HIV infection and AIDS.as. MUDr. M. Chadimovámalá posluchárna9. Mo 11:15 - 13:50 Practical training Autopsy demonstrations.Gross and microscopic pathology:a) infectious diseasesb) transplantationc) regeneration, hypertrophy, hyperplasiaas. MUDr. J. Háček, as. MUDr. P. ŠkapaÚPMM 2A a budova 11Th 11:00 - 13:35 Lecture Pathology of diseases of the immunity.Pathology of transplantations.as. MUDr. M. Chadimovámalá posluchárna10. Mo 11:15 - 13:50 Practical training Autopsy demonstrations.Gross and microscopic pathology: repetionprim. MUDr. D. Kodetová, as. MUDr. Š. CiproÚPMM 2A a budova 11Th 11:00 - 13:35 Lecture 1. Cysts: classification, morphology2. General oncology I. Oncogenes, supressor genes:a) activation of oncogenes retroviral insertion mutagenesis, experimental cellular transformation chromosomal translocations amplification point mutationsb) supressor genes two hit theory, A. Knudson, retinoblastoma other supressor genes - p53, WT1c) products of oncogenes, signal transduction pathways, regulatory mechanisms of cell kineticsprof. MUDr. R. Kodet, CSc.malá posluchárna11. Mo 11:15 - 13:50 Practical training Autopsy demonstrations.Gross and microscopic pathology: cystsas. MUDr. V. Campr, doc. MUDr. J. Zámečník, Ph.D.ÚPMM 2A a budova 11Th 11:00 - 13:35 Lecture General oncology II.1. Tumor growth and metastasizing:a) clonal versus polyclonal tumor development, tumor cell cycle and means of its detection; life span of tumorsb) heterogeneity of tumor cell populationsc) tumor cell invasiond) development of metastatic spread, homing phenomenon; adhesion molecules;2. Incidence of tumors:a) most frequent malignant tumors in adults, sex-related differencesb) distinction between incidence of tumors in adults and childhoodprof. MUDr. R. Kodet, CSc.malá posluchárna12. Mo 11:15 - 13:50 Practical training Autopsy demonstrations.Gross and microscopic pathology: Epithelial, mesenchymal and germ cell tumors, other neoplasmsas. MUDr. M. Grega, as. MUDr. M. ChadimováÚPMM 2A a budova 11Th 11:00 - 13:35 Lecture General oncology III. Classification of tumors:1. Epithelial tumors and their behaviora) tumors of surface epithelia (papillomas; precancerous lesions of the skin, uterine cervix, other; squamous cell carcinoma, basal cell carcinoma);b) tumors of the glandular and organ origin (adenomas, adenocarcinomas - gross and microscopic evaluation, biological properties, organ examples).2. Mesenchymal tumors, tumors of the peripheral nerves, pigmented nevi and melanoma, teratomas, choriocarcinoma, mesothelioma - general featuresprof. MUDr. R. Kodet, CSc.malá posluchárna13. Mo 11:15 - 13:50 Practical training Autopsy demonstrations.Gross and microscopic pathology: cysts and neoplastic diseases repetitionas. MUDr. M. Grega, as. MUDr. M. ChadimováÚPMM 2A a budova 11Th 11:00 - 13:35 Lecture Pathology of the heart I.1. Congenital malformations:a) classification, diagnosisb) basic clinico-pathologic correlations2. Ischemic heart disease:a) pathogenesis, changes of the coronary vesselsb) morphologyc) development and complicationsprof. MUDr. R. Kodet, CSc.malá posluchárna14. Mo 11:15 - 13:50 Practical training Autopsy demonstrations.Gross and microscopic pathology: Cardiopathologyas. MUDr. Š. Cipro, as. MUDr. M. GregaÚPMM 2A a budova 11Th 11:00 - 13:35 Lecture Pathology of the heart and vessels II.1. Myocarditis. Cardiomyopathies2. Acquired diseases of the heart valves andtheir complications: endocarditis rheumatic fever bacterial endocarditis3. Pathology of the vessels:a) atherosclerosisb) vasculitisc) aneurysmsprof. MUDr. R. Kodet, CSc.malá posluchárnaSchedule for group No. 1:Week Day - Time Type Content20. Mo 8:00 - 9:00 Seminar Pathology of the pericardiumhydropericardium, hemopericardium // inflammation non specific, tuberculosisArterial aneurysmsPathology of the veins and lymphatic vesselsthrombosis and its complications // thrombophlebitis // lymphedema, erysipelasprim. MUDr. D. KodetováDpt. of PathologyMo 9:00 - 11:30 Practical training Pathology of the heart // pathology of the arteriesas. MUDr. M. Grega, as. MUDr. J. Háček,Dpt. of PathologyFr 9:00 - 12:35 Lecture Pathology of the hemopoietic systemRed blood cell disordersAnemias: definition, classification posthemorrhagic anemias hemolytic anemias - corpuscular / extracorpuscular anemias of diminished erythropoiesisiron deficiency and megaloblastic anemiasaplastic anemiasPolycythemiaWhite blood cell disordersReactive conditions: leucocytosis, leukopenia // infectious mononucleosisLeukemias and myeloproliferative diseases: classification // leukemias / classificationprof. MUDr. R. Kodet, CSc.small left21. Mo 8:00 - 9:00 Seminar Myelodysplastic syndrome. Myeloproliferative diseases.as. MUDr. V. CamprDpt. of PathologyMo 9:00 - 11:30 Practical training Anemias // leukemias // recap. cardiovascular pathologyas. MUDr. V. Campr , as. MUDr. M. GregaDpt. of PathologyFr 9:00 - 12:35 Lecture Pathology of the lymph nodes and lymphomasreactive changes // inflammation // non-Hodgkin´s malignant lymphomas // Hodgkin´s disease; classification, morphology, diagnosisPlasma cell disordersas. MUDr. J. Soukupsmall left hall22. Mo 8:00 - 9:00 Seminar Pathology of the pleural cavityhydrothorax, pneumothorax // pleuritis nonspecific, tuberculous // asbestosis, mesotheliomaMalformations of the respiratory systemPathology of the mediastinumas. MUDr. Š. CiproDpt. of PathologyMo 9:00 - 11:30 Practical training Pathology of the hemopoetic system. Pathology of the lymph nodesas. MUDr. Š. Cipro, as. MUDr. M. GregaDpt. of PathologyFr 9:00 - 12:35 Lecture Pathology of the respiratory system IObstructive lung diseasesasthma bronchiale // chronic obstructive lung disease // chronic bronchitis // emphysema // bronchiectasisRestrictive lung diseasesacute - adult respiratory distress syndrome // chronic - idiopathic pulmonary fibrosis // sarcoidosisVascular lung diseasespulmonary embolism, infarction, hemorrhage // pulmonary hypertensionprof. MUDr. R. Kodet, CSc.small left hall23. Mo 8:00 - 9:00 Seminar Appendicitis acute, morphologic types, evolution, complication // chronic, evolution, complicationsas. MUDr. M. GregaDpt. of PathologyMo 9:00 - 11:30 Practical training Pathology of the lungsas. MUDr. J. Soukup, as. MUDr. J. HáčekDpt. of PathologyFr 9:00 - 12:35 Lecture Pathology of the respiratory system IIPulmonary infectionsacute bacterial pneumonia // “atypical’ pneumonias // chronic pneumonia // tuberculosisLung tumorsbronchogenic carcinoma // bronchial carcinoid and other tumorsas. MUDr. L. Čapkovásmall left hall24. Mo 8:00 - 9:00 Seminar Pathology of the biliary tractmalformations of the biliary tract // biliary atresia // biliary obstruction // acute and chronic inflammations // carcinoma of the biliary ductsas. MUDr. J. SoukupDpt. of PathologyMo 9:00 - 11:30 Practical training Recap. pathology of the lungsas. MUDr. J. Soukup, as. MUDr. J. HáčekDpt. of PathologyFr 9:00 - 12:35 Lecture Pathology of the GIT IOral cavityinflammations // carcinoma // salivary gland inflammations, tumorsOesophagusdisorders of mobility, diverticula, varices // reflux esophagitis // esophageal carcinomaStomachgastritis // peptic ulcer // gastric polyps // carcinoma, lymphoma, stromal tumorsas. MUDr. J. Soukupsmall left hall25. Mo 8:00 - 9:00 Seminar Pathology of the peritoneal cavityhernias acquired external and internal, congenital // inflammation - diffuse and circumscribed non-specific peritonitis, acute and chronic // tuberculosis; carcinosis of the peritoneumas. MUDr. P. ŠkapaDpt. of PathologyMo 9:00 - 11:30 Practical training Pathology of the oesophagus and stomachas. MUDr. M. Chadimová, as. MUDr. M. GregaDpt. of PathologyFr 9:00 - 12:35 Lecture Pathology of the GIT IISmall and large intestinevascular disorders // inflammatory diseases // Crohn´s disease // ulcerative colitis // infections enterocolitis // malabsorption syndromes // polyps , polyposis // colorectal carcinoma; lymphomas; stromal tumorsprof. MUDr. R. Kodet, CSc.small left hall26. Fr 9:00 - 12:35 Lecture Pathology of the liverliver cell necrosis // toxic and drug-induced liver disease // vascular disorders // viral hepatitis, classification, morphology, clinicopathologic correlations // liver cirrhosis, classification, pathogenesis, complications, portal hypertension // tumors - carcinoma, hepatoblastomaprof. MUDr. R. Kodet, CSc.small left hall27. Mo 8:00 - 9:00 Seminar Pathology of the exocrine pancreasas. MUDr. Š. CiproDpt. of PathologyMo 9:00 - 11:30 Practical training Pathology of the small and large bowel - inflammation, neoplasms. Pathology of the biliary tree.doc. MUDr. J. Zámečník, Ph.D., as. MUDr. P. ŠkapaDpt. of PathologyFr 9:00 - 12:35 Lecture Pathology of the kidneysvascular disorders, necrosis // acute and chronic interstitial nephritis // glomerular diseases (mechanism of glomerular injury, the nephrotic syndrome, the nephritic syndrome) // renal cell carcinoma, renal tumors in children as.as. MUDr. M. Chadimovásmall left hall28. Mo 8:00 - 9:00 Seminar Pathology of the breastmalformations // inflammation during lactation, other // fibrocystic disease // tumors - benign // malignant: carcinoma, classification, morphology, clinicopathologic correlationas .MUDr. J. SoukupDpt. of PathologyMo 9:00 - 11:30 Practical training Pathology of the kidneys and urinary tract; pathology of the breastas. MUDr. M. Chadimová, as .MUDr. J. SoukupDpt. of PathologyFr 9:00 - 12:35 Lecture Pathology of the female genital system IPathology of the external genitalia, vagina and uteruscervix - cervicitis // cervical intraepithelial neoplasia // carcinoma // corpus - inflammations // carcinoma and precancerous lesions // leiomyoma, sarcomas; mixed tumorsPathology of the Fallopian tubes and ovariesinflammation acute, chronic, consequences // non-neoplastic ovarian cysts // tumors - surface epithelial tumors // germ cell tumors // gonadal stromal tumors // metastatic tumorsas. MUDr. P. Škapasmall left hall29. Mo 8:00 - 9:00 Seminar Pathology of the male genital system - prostate hyperplasia, imflammation, carcinomaas. MUDr. V. CamprDpt. of PathologyMo 9:00 - 11:30 Practical training Pathology of the female and male genital tractprim. MUDr. D. Kodetová, as. MUDr. Š. CiproDpt. of PathologyFr 9:00 - 12:35 Lecture Pathology of the female genital system IIDiseases of the pregnancyplacental abnormalities, inflammation // ectopic pregnancy // trophoblastic disease - hydatidiform mole, invasive mole, choriocarcinomaPathology of the male genital systempenis - malformations, precancerosis, carcinoma // scrotum, testis and epidydimis cryptorchidism, inflammation - acute suppurative, viral, tbc, tumors // germ cell tumors, stromal tumors, otheras. MUDr. P. Škapasmall left hall30. Mo 8:00 - 9:00 Seminar Interstitial nephritis - pathogenesis and classificationPathology of kidney transplantationas. MUDr. M. ChadimováDpt. of PathologyMo 9:00 - 11:30 Practical training Pathology of the female and male genital systemas. MUDr. M. Chadimová, as. MUDr. J. SoukupDpt. of PathologyFr 9:00 - 12:35 Lecture Pathology of the brain IBasic reactions of neurons and glial cellsCommon pathophysiologic disordersincreased intracranial pressure // cerebral edema // hydrocephalusVascular diseases - hypoxic encephalopathy, cerebral ischemia, intracranial hemorrhageInfections - meningitis // encephalitis bacterial, viral acute, slow viral infections, spongiform encephalopathiesdoc. MUDr. J. Zámečník, Ph.D.small left hall31. Mo 8:00 - 9:00 Seminar Brain tumors - classification, clinicopathological correlationPathology of peripheral nerves - degeneration, regeneration, peripheral neuropathiesdoc. MUDr. J. Zámečník, Ph.D.Dpt. of PathologyMo 9:00 - 11:30 Practical training Pathology of the brainas. MUDr. P. Škapa, as. MUDr. Š. CiproDpt. of PathologyFr 9:00 - 12:35 Lecture Pathology of the brain IIDegenerative diseasesSenile atrophy and Alzheimer´s disease // Huntington disease // Parkinsonism // Amyotrophic lateral sclerosisDemyelinating diseasesmultiple sclerosisMetabolic disorderscobalamin deficiency, thiamin deficiency, metabolic encephalopathiesInborn errors of metabolismWilson´s disease // leukodystrophiesdoc. MUDr. J. Zámečník, Ph. D.small left hall32. Mo 8:00 - 9:00 Seminar Pathology of the skinskin precancerous lesions (solar keratosis, Bowen´s disease) // skin tumors ( karcinoma of the skin, skin adnexal tumors, skin mesenchymal tumors) // pigmented nevi // melanoma and its classificationprim. MUDr. D. KodetováDpt. of PathologyMo 9:00 - 11:30 Practical training Pathology of the central nervous systemas. MUDr. V. Campr, as. MUDr. J. HáčekDpt. of PathologyFr 9:00 - 12:35 Lecture Pathology of the bones and jointsMetabolic diseases - osteoporosis // rickets and osteomalacia // osteitis fibrosa cystica // renal osteopathiesInflammation pyogenic osteomyelitis // Paget´s diseaseFibrous dysplasiaBone tumors - classification, clinicopathologic correlationprof. MUDr. R. Kodet, CSc.small left hall33. Mo 8:00 - 9:00 Seminar Creditprof. MUDr. R. Kodet, CSc.Dpt. of PathologyMo 9:00 - 11:30 Practical training Pathology of the bones and jointsprim. MUDr. D. Kodetová, as. MUDr. P. ŠkapaDpt. of PathologyFr 9:00 - 12:35 Lecture Pathology of the endocrine systemDiabetes mellitusclassification // pathogenesis // pathogenesis of complicationsPituitary gland, tumors, basic syndromesThyroid gland - Grave´s disease, thyroiditis // diffuse and multinodular goiter // tumors, classification, clinicopathologic correlationMultiple endocrine neoplasiaprof. MUDr. R. Kodet, CSc.small left

Literatura

Kumar, V.: Robbins basic pathology : W. B. Saunders company,8thed. 2007 (B), (avaible as ebook)orKumar, V.: Robbins basic pathology : 9th ed. 2012orLevison, D. A.: Muir ́s textbook of pathology : Hodder Arnold, 14th ed. 2008

Garant

prof. MUDr. Roman Kodet, CSc.