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Předmět Biochemie II (FD10017)

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Další informace

Sylabus

 LecturesIntroduction to Metabolism of Proteins and Amino Acids. Transamination, Oxidative Deamination and Decarboxylation of Amino Acids. Catabolism of the Carbon Skeleton of Amino Acids. Ammonia Formation and its Removal. Proteolytic Enzymes and Parodontitis. (Řezáčová 4)Metabolism of Connective Tissue. Connective Tissue Proteins - Collagen and Elastin. Lack of Vitamin C. Periodontal Ligamentum. Proteoglycans. Metabolism of Muscles. (Mrkvicová 5) Metabolism of Porphyrins and Bile Pigments. Biosynthesis of Haeme and Haemoglobin and their Catabolism. Biochemistry of Saliva.  (Řezáčová 1)Calcified Tissues - Composition, Calcification of Bones, Dentine, Enamel, Cementum.Process of Mineralization. Hormones in Mineralization. Dental Plaque and its Metabolism. (Mrkvicová 3) Regulation of Metabolism. (Mrkvicová 2)  Practical courses & seminarsLecturersAssoc. Prof. Jaroslav Cerman, M.D., Ph.D.Dr. Renata Kohlerová, Ph.D.Dr. Mohamed Niang, Ph.D.Prof. Martina Řezáčová, M.D., Ph.D.Assoc. Prof. Alena Stoklasová, M.D., Ph.D.Pavel Tomšík, M.D., Ph.D.Dr. Alena Mrkvicová, Ph.D.Ïng. Milos Hroch, Ph.D.prof. Jiri Stulik, Ph.D.Dr. Darina Muthná, Ph.D.SeminarsMetabolism of Lipids - Digestion, Absorption, Transport. Metabolism of Fatty Acids, Triacylglycerols and Complex Lipids. Metabolism of Lipoproteins and Eicosanoids. Metabolism of Steroids. Ketogenesis. Test.Metabolism of Amino Acids and Proteins- Digestion, Absorption, Degradation of Proteins. Importance in Dentistry.Metabolism of Amino Acids. Biosynthesis of Urea. Test.Nucleic Acids, Proteosynthesis.Metabolism of Porphyrins and Bile Pigments.The Blood, Blood Clotting.Acid-Base Balance. Saliva, Gingival Juice.Biochemistry of Contractile Tissues. Connective Tissue.  Test.Bones and Teeth and their Physical and Chemical Characteristics. Minerals. Importance in Dentistry.Mineralization. Metabolism of Water and Ions, Homonal Control. Test.Receptors. Extracellular and Intracellular Communication. Pituitary and Hypothalamic Hormones.Pulp, Periodontal Ligamentum, Plaque and its Metabolism. Tooth pastes. Test.Steroid Hormones, Thyroid Hormones, Hormones of the Pancreas and Adrenals.Metabolism of Xenobiotics. Immunochemistry.Effect of Nutrition on Calcified Tissues. Revision Seminar.   Practical coursesConcentration of Glucose in the Serum. Concentrations of Total and HDL-Cholesterol. Triacylglycerols in the Serum.Protein Concentration in the Serum. Separation of the Serum Proteins by Electrophoresis.Concentrations of Urea and Uric Acid in the Serum. Concentration of Creatinine in the Serum and Urine.Concentrations of Calcium and Phosphates in the Serum. Concentration of Chlorides in the Urine.Iron Concentration in the Serum. Total and Conjugated Bilirubins in the Serum. Concentration of Sodium and Potassium in the Serum. Notes: Attendance at practical classes and seminars is COMPULSORY and a register is kept. For unavoidable absences (e. g. illness) a written note must be given to doc. Stoklasová immediately on your return. 

Literatura

Compulsory literatureR. Y. Ouellette Introduction to General, Organic and Biological Chemistry. 3rd ed., Mac Millan Publ.Company, New York, 1992. ISBN 0-02-390245-0 (or the latest edition available)R. K. Murray et al. Harper's Biochemistry. 24th ed., Appleton and Lange, Stamford, USA, 1996.ISBN 0-8385-3612-3. (or the latest edition available)Recommend literatureP. C. Champe and R.A.Harvey Biochemistry. Lippincott Co, 1987. ISBN 0-397-50801-8 (or the latest edition available)J.W. Baynes et M. H. Dominiczak Medical Biochemistry. 4th ed., Elsevier 2014. ISBN 978-1-4557-4580-7 

Požadavky

Credita) Attendance at practical classes and seminars (3 absences will be tolerated).b) Complete protocols.c) At least pass average (3.00) in written tests and oral examinations. Substitution of test you miss is necessary to discuss with doc. A. Stoklasová. ExaminationThe examination consists of two parts - multiple choice questionnaire test and oral examination - and it is conditioned with having both credits. Written test:  at least 11 points are necessary for oral part of examination. The students who fail to satisfy the requirements of the examination are re-examined orally (two possibilities). 

Garant

doc. MUDr. Alena Stoklasová, CSc.