Předmět Farmakologie I (FG10028)

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Materiál	Typ	Datum	Počet stažení

Sylabus

LecturesBasic principles of pharmacology. Pharmacodynamics. (Micuda 3) Pharmacokinetics. Pharmacokinetic parameters. (Chladek 3) Adverse and toxic effects. Drug interactions. (Sterba 3) Cholinergic transmission: cholinergic agonists and antagonists. (Lenčová 3) Noradrenergic transmission: adrenergic agonists and antagonists. Opioid analgesics. (Micuda 3) Opioid and non-opioid analgesics/Non-stereoidal Anti-inflammatory Drugs (NSAIDs). (Micuda 2)Practical courses & seminarsLecturersProf. Stanislav Micuda, M.D., Ph.D.Assoc. Prof. Dr. Martin Sterba, Ph.D.Assoc. Prof. Jaroslav Chladek, M.Sc., Ph.D.Jolana Cermanova, M.D., Ph.D.PharmDr. Olga Lenčová, Ph.D.Mgr. Eduard Jirkovský, Ph.D.Basic principles of pharmacology. Pharmacodynamics. The seminar on: Nature of drug targets, receptors and their types. Well-established second messengers. Dose-response curve. Potency and efficacy. Agonists and antagonists. Up and down regulations. Variation in drug responsiveness. Practical demonstrations: PC simulation - Isolated ileum stimulation. Drugs available: acetylcholine, atropine, papaverine, physostigmine, carbachol, methacholine. Topics: Agonists and antagonists. Dose- respose curve construction and its modification. The demonstration will be performed by the lecturer.Pharmacokinetics of the drugs. The seminar on: Main mechanisms determining pharmacokinetics of a drug (physico-chemical properties, permeation through biomembranes, binding). Absorption, distribution, metabolism, excretion (ADME). Pharmacokinetic parameters, pharmacogenetics, bioavailability, bioequivalence. Practical demonstrations: PC simulation using the PkSims software. Practical demonstration of the influence of the route of administration and dosing regimen on the pharmacokinetics. Calculation of bioavailability. Pharmacokinetics after continuous and continuous-intermittent dosing. Linear and nonlinear pharmacokinetics. The demonstration will be performed by the lecturer.Adverse and toxic effects of drugs. Drug interactions. Drug development. The seminar on: the above given topics, drug information and its sources. Practical demonstrations: AISLP (Electronic version of the Czech Drug Formulary). The demonstration will be performed by the lecturer.Drugs affecting cholinergic transmission: cholinergic agonists & antagonists. The seminar on: the above given topic. Practical demonstrations: PC simulation - Cardio heart rate and blood pressure (in vivo). Drugs available: acetylcholine, atropine, neostigmine, hexamethonium. The demonstration will be performed by the lecturer.Drugs affecting adrenergic transmission: adrenergic agonists & antagonists. The seminar on: the above given topic. Practical demonstrations: PC simulation - Cardio heart rate and blood pressure (in vivo). Drugs available: adrenaline, noradrenaline, isoprenaline, prazosine, propranolol, atenolol, cocaine, tyramine. The demonstration will be performed by the lecturer.Control of pain - seminar. Basic and clinical pharmacology of analgesics, both opioid and non-opioid (including NSAIDs!). Case report: Postoperative pain in children.Neuroleptic, antidepressant agents, anxiolytics - microlesson and seminar. Video recording: Extrapyramidal syndrome due to neuroleptics.Hypno-sedatives, antiparkinsonics and antiepileptics - microlesson and seminar. Practical demonstrations: Therapeutic drug monitoring (TDM) in antiepileptic therapy.Skeletal muscle relaxants. General and local anesthetics. The seminar on: the above given topic. The Credit.Notes Students are supposed to be theoretically prepared on each practical lesson/seminar and the understanding to the topic will be regularly examined (MCQ tests/written tests/oral examination).  

Literatura

Compulsory literature Katzung BG, Masters SB, Trevor AJ: Basic and Clinical Pharmacology, 11th ed., McGraw Hill Lange, 2009. ISBN 978-0-07-160404-5.Recommend literature Rang HP, Dale MM, Ritter JM: Pharmacology. 6th ed., Churchill Livingstone, 2007. Standard ed. ISBN 00443069115.Harvey RA: Lippincott´s Illustrated Reviews: Pharmacology, 2012, 5th ed., Lippincott Williams and Wilkins, ISBN 1451113145Completive literature Lectures in electronic form (https://moodle.lfhk.cuni.cz/).

Požadavky

CreditThe attendance on practical classes is compulsory (only one absence is acceptable). The average from all classifications in the term (semester) must be below or equal to 3.00 In the case of failure to meet the conditions for the credit: The case of two absences - the student will be examined in depth from the topics of both practical classes on which the student was absent. The case of three or more absences - the student will be examined from the topics covering the whole term (semester). The case of the average grading > 3.00 - the student will be examined from the topics covering the whole term (semester).

Garant

prof. MUDr. Stanislav Mičuda, Ph.D.