Předmět Farmakologie II (FG10036)

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Materiál	Typ	Datum	Počet stažení

Sylabus

LecturesLecturersProf. Stanislav Mičuda, M.D., Ph.D.Assoc. Prof. Martin Štěrba, PharmD., Ph.DAssoc. Prof. Jaroslav Chládek, MSc., Ph.D.Hormones - insulin and insulin analogues, oral antidiabetics. (Mičuda, 2)Histamine, antihistamines. Drugs affecting hemostasis. (Chládek, 3)Antiarrhythmic drugs, cardiac glycosides. (Štěrba, 2)Drugs affecting RAAS, drugs affecting vascular tonus. (Štěrba, 2)Drugs affecting vascular tonus, diuretics. Overview of pharmacological treatment of hypertension and ischemic heart diseases. (Štěrba, 2)Hormones - corticosteroids. (Mičuda, 2)Overview of pharmacological treatment of heart failure. Hormones - sexual hormones. (Mičuda,2)Hormones - thyroidal. Antibacterial drugs - general pharm., beta-lactams, vancomycine. (Mičuda, 2)Antibacterial drugs - tetracyclines, macrolides, aminoglycosides. (Mičuda, 2)Antibacterial drugs - sulfonamides, quinolones, other ATB. (Mičuda, 2)Antitubercular drugs, antimycotics and overview of antiviral agents. (Chládek, 2)Anticancer drugs - general pharmacology and overview of drugs. (Chládek, 2) Practical courses & seminarsLecturersProf. Stanislav Mičuda, M.D., Ph.D.Assoc. Prof. Martin Štěrba, PharmD., Ph.D.Assoc. Prof. Jaroslav Chládek, MSc., Ph.D.Jolana Cermanová, M.D., Ph.D.Eduard Jirkovský, Mgr., Ph.D.Drug dependence and abuse, revision of CNS pharmacology - microlesson and seminar. General pharmacology of drug dependence, drugs and agents inducing dependence. Revision of CNS affecting drugs related to the topics (esp. hypnosedatives and opioids). Test.Antiasthmatics, histamin and antihistamines - microlesson and seminar. Basic and clinical pharmacology. Approach to asthma management. Practical demonstrations: Handling different types of inhalers. Test.Drugs used in altered states of hemostasis (bleeding and thrombosis) - seminar. Basic and clinical pharmacology. Therapy of thrombosis and monitoring of therapy with anticoagulants. Case reports. Test.Cardiac glycosides, drugs affecting RAAS, diuretics - seminar. Basic and clinical pharmacology.Test.Drugs affecting vascular tonus, pharmacological treatment of angina, hypertension and heart failure - seminar. Basic and clinical pharmacology. Test.Drugs acting on the gastrointestinal tract. Hypolipidemic drugs - microlesson and seminar. Test.Pharmacology of hormones - insulin and antidiabetics, corticoids - microlesson and seminar. Test.Antibiotics I - seminar. Beta-lactams, aminoglykosides, glycopeptides, clindamycin, chloramphenicol, macrolides Case reports: Nephrotoxicity of aminoglycosides. Demonstrations: TDM of antibiotics (aminoglycosides, vancomycin). Aminoglycosides OD. Test.Antibiotics II - seminar. Quinolones, sulphonamides, urinary tract antiseptics, antimycobacterial and antifugal drugs. Test.Anticancer chemotherapy - microlesson and seminar. Basic pharmacology of cytostatics. Test.Factors influencing the response to a drug. a. depending on the drug: physico-chemical features, route of administration, drug formulation, food; b. depending both on the drug and on the body: dose, repeated administration (accumulation, tolerance), coadministration with other drugs (synergism, antagonism), delayed effects; c. depending on the body: gender, age, genetic information, pathological state. Demonstration: digoxin and lignocaine in kidney and liver failure. Test.Basic information on pharmaceutical dosage forms, prescription writing - microlesson and seminar. Test and credit.Notes:1) Students are supposed to be theoretically prepared on each practical lesson/seminar and the understanding to the topic will be regularly examined (MCQ tests/written tests/oral examination). 

Literatura

 Compulsory literatureKatzung BG, Masters SB, Trevor AJ: Basic and Clinical pharmacology, 11th ed., McGrawHill Lange, 2009. ISBN 978-0-07-160405-5Recommend literatureRang HP, Dale MM, Ritter JM: Pharmacology. 6th ed., Churchill Livingstone, 2007. Standard ed. ISBN 00443069115Harvey RA: Lippincott´s Illustrated Reviews: Pharmacology, 2012, 5th ed., Lippincott Williams and Wilkins, ISBN 1451113145Completive literatureLectures in electronic form (https://moodle.lfhk.cuni.cz/)

Požadavky

Credit: The attendance on practical classes is compulsory (only one absence is acceptable). The average from all classifications in the term (semester) must be below or equal to 3.00 In the case of failure to meet the conditions for the credit: The case of two absences - the student will be examined in depth from the topics of both practical classes on which the student was absent. The case of three or more absences - the student will be examined from the topics covering the whole term (semester). The case of the average grading > 3.00 - the student will be examined from the topics covering the whole term (semester).Examination:Only students with the credits from both semesters (winter and summer) written in their indexes are eligible for the final exam. Final exam consists of MCQ test and oral examination. Those students who have the average classification grading in both semesters below or equal 2.00 (considered separately) are allowed to omit the MCQ test and enter directly the oral part of the examination. Even in the case of failure in the written part of the exam, the student can pass forward to the oral part of the examination; however, this result will be reflected in the final classification. The results of the written part of the examination are included in the final classification grading (if applicable). Further details to the organisation of the final examinations will be given in advance on the Department’s board.  

Garant

prof. MUDr. Stanislav Mičuda, Ph.D.