Předmět Patobiochemie buňky (FG50036)
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Další informace
Sylabus
LecturersProf. Dr. Emil Rudolf, Ph.D.Prof. Martina Řezáčová, M.D., Ph.D.Assoc. Prof. Dr. Martin Beránek, Ph.D.Assoc. Prof. Jaroslav Cerman, M.D., Ph.D.Assoc. Prof. Alena Stoklasová, M.D., Ph.D.Oxidative stress. Reactive oxygen and nitrogen species, their production and effects on molecular level. Defence systems - enzymes (superoxide dismutase, glutathione peroxidase, catalase), vitamins (carotenes, tocopherols, vitamin C, Q10), naturally occurring low molecular weight compounds. (Stoklasová 3)Pathobiochemistry of cell death. Cellular transmembrane communication. Molecular aspects of transmembrane signalling in tumor cells; enzyme activity of receptor molecules, structure and posttranslational modifications of crucial molecules in cell death and apoptosis (caspases, bcl-2 family proteins, p53), DNA damage signalling and repair, role of histone modification. (Řezáčová 3)Pathobiology of cell death. Intercellular communication. System of classification of cell death in malignant cells in historical and contemporary context, involvement of non-canonical cell death programmes, the position of different organelles in initiation and execution of cell death, the role of selected proteins such as Hsp and BH-3 domain family in death signalling. (Rudolf 3)Gene mutations: origin and progress of tumours. The significance of gene analysis for exact pathological classification and therapy: Examples of some CNS tumours. (Cerman 2)Analytical methods in diagnostics and monitoring of anti-tumour treatment. Preparation of nucleic acids before molecular biology tests, standard and real-time PCR, mini-training in nucleotide sequence reading, quantitative molecular biology methods, micro-chips, detection of mutations, strategy of molecular methods in cancer diagnostics, clinical examples. (Beránek 4)
Požadavky
Credit: Attendance. Credit test: focused on basic knowledge of topics 1-3, basic knowledge of NA..
Garant
prof. MUDr. Martina Řezáčová, Ph.D.prof. PharmDr. Emil Rudolf, Ph.D.