Předmět Imunologie (EA0105085)

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Materiál	Typ	Datum	Počet stažení

Sylabus

Immunology 3rd year - General medicine 2015/20169. 10. 2015 Doc. MUDr. Petr Panzner, CSc.1. Immune system and its importance for homeostasis. Component parts of the immune system and their cooperation.2. Barrier functions of the human body and defense mechanisms.3. Non-specific cellular and humoral immune mechanisms.4. Specific cellular and humoral immune mechanisms.5. Phagocytosis and its importance for immunity.6. Neutrophils, their ontogenesis and function.7. Natural killer cells. Interferons. Characteristics and function. 16. 10. 2015 Mgr. Jitka Ochotná8. Complement, pathways of activation, biological significance.9. Alternative pathway of complement activation and its regulation.10. Classical pathway of complement activation and its regulation.11. Biological significance of complement and its mechanisms of regulation.12. Basophils and mast cells and their role in the immune reactions.13. Immune mechanisms of the inflammation (local and systemic reaction).14. Antigen, hapten, epitop - basic characteristics. T-independent antigens, superantigens.  Sequestered antigens - immunologically privileged tissue.15. Chemical nature and molecular size of antigens. Degree of foreignness. 23. 10. 2015 MUDr. Martin Liška, PhD.16. HLA system, 1st class molecules, their structure and function.17. HLA system, 2nd class molecules, their structure and function.18. HLA system, genetic background. HLA typing.19. Macrophages, dendritic cells, their ontogenesis and function.20. B-lymphocytes - ontogenesis, surface markers, function.21. Primary immune organs and their role in the immune system.22. Secondary immune organs - structure and function of lymphatic node and spleen.23. Mucosal immune system. 30. 10. 2015 Doc. MUDr. Petr Panzner, CSc.24. Antigen presenting cells - types, function.25. Modes of antigen presentation.26. T-lymphocytes, ontogenesis, surface markers. Subpopulations of T-lymphocytes and their  functions.27. The role of thymus. Positive and negative selection of T-lymphocytes.28. Th1 based immune reaction.29. Th2 based immune reaction.30. Tc based immune reaction. 6. 11. 2015 MUDr. Martina Vachová31. Immunoglobulins - structure.32. Immunoglobulins - function.33. Genetic background of immunoglobulin production.34. Biological and chemical characteristics of immunoglobulin classes IgG and IgA.35. Biological and chemical characteristics of immunoglobulin classes IgM, IgD and IgE.36. Isotype switching. Idiotypes and anti-idiotypes - their role. Immunological memory.37. Ontogenesis of the immune response.38. Primary immune response.39. Secondary immune response. Effector functions of antibodies. 13. 11. 2015 Mgr. Jitka Ochotná40. Cytokines (overview, disposal according their functions).41. Physiological mechanisms of regulation of the immune system. Cytokines.42. Possibilities of therapeutic affecting of the immune system - immunomodulation,  substitution, suppression.43. Active and passive immunization.44. Defense against extracellular pathogens (bacteria and unicellular parasites).45. Defense against multicellular parasites.46. Defense against intracellular pathogens (bacteria and unicellular parasites).47. Anti-viral defense.  20. 11. 2015 MUDr. Martina Vachová48. Radioimmunoassay, enzymoimmunoassay - principles, practical use.49. Laboratory measurement of specific IgE antibodies.50. Laboratory measurement of autoantibodies.51. Flow cytometry - principles, practical use.52. Laboratory methods of assessment of cellular immunity.53. Laboratory methods of assessment of humoral immunity.  27. 11. 2014 MUDr. Martina Vachová54. Non-organ-specific autoantibodies and their diagnostic significance.55. Autoantibodies in organ specific autoimmune diseases. Organ-localized autoimmune diseases with non-organ-specific autoantibodies.56. Autoimmune diseases - pathophysiology, division, laboratory diagnostics, treatment.57. Examples of systemic autoimmune diseases.58. Examples of organ-specific autoimmune diseases.59. Immunosupressive treatment - examples of drugs, indications, risks. 4. 12. 2014 MUDr. Martin Liška, PhD.60. Immunodeficiency - characteristics, division, clinical manifestations, treatment.61. Primary immunodeficiencies - examples.62. Immunoglobulin replacement therapy.63. Acquired immunodeficiencies - causes. AIDS.64. Deficiency of complement components. Hereditary angioedema 11. 12. 2015 Mgr. Jitka Ochotná65. Tumor immunology - tumor antigens, mechanisms of defense.66. Immunological examination before transplantation (examination of sensitization, HLA typing).67. Transplantation immunity - alloimmune reaction.68. Types of graft rejection.69. Immunopathological reaction (reaction of hypersensitivity) type II. Principles.  Examples of pathological conditions.70. Immunopathological reaction (reaction of hypersensitivity) type III. Principles. Examples of pathological conditions.71. Immunopathological reaction (reaction of hypersensitivity) type IV.Principles.  Examples of pathological conditions.  18. 12. 2014 Doc. MUDr. Petr Panzner, CSc.72. Immunopathological reaction (reaction of hypersensitivity) type I.73. Allergens - definition, division and nomenclature.74. Anaphylaxis - pathophysiology, clinical manifestation, treatment.75. Diagnostic procedures used in allergology.76. Treatment of allergic diseases.77. Examples of diseases based on immunopathological reaction of type I. 8. 1. 2016 Prof. MUDr. Ulčová-Gallová, DrSc.78. Primary and secondary antiphospholipide syndrome.79. Immune mechanisms of male infertility.80. Immune mechanisms of female infertility.81. Neuro-endocrine-immunologic interrelationships in gravidity. Principle of materno-foetal tolerance. Rh incompatibility.  

Literatura

Abbas A. K., Lichtman A. H. H., Pillai S.: Basic Immunology: Functions and Disorders of the Immune Systém. Elsevier Health Sciences, 2012Doan T., Melvold R., Viselli S., Valtenbaugh C.: Immunology. Lippincott Williams & Wilkins, 2012  

Požadavky

Questions to the exam (from Immunology) for 3rd year GM 2014-2015Immune system and its importance for homeostasis. Component parts of the immune system and their cooperation.Barrier functions of the human body and defense mechanisms.Non-specific cellular and humoral immune mechanisms.Specific cellular and humoral immune mechanisms.Phagocytosis and its importance for immunity.Neutrophils, their ontogenesis and function.Natural killer cells. Interferons. Characteristics and function.   Complement, pathways of activation, biological significance.Alternative pathway of complement activation and its regulation.Classical pathway of complement activation and its regulation.Biological significance of complement and its mechanisms of regulation.Antigen, hapten, epitop - basic characteristics. T-independent antigens, superantigens. Sequestered antigens - immunologically privileged tissue.Chemical nature and molecular size of antigens. Degree of foreignness.Basophils and mast cells and their role in the immune reactions.Immune mechanisms of the inflammation (local and systemic reaction).Cytokines (overview, disposal according their functions).Physiological mechanisms of regulation of the immune system. Cytokines.HLA system, 1st class molecules, their structure and function.HLA system, 2nd class molecules, their structure and function.HLA system, genetic background. HLA typing.Macrophages, dendritic cells, their ontogenesis and function.T-lymphocytes, ontogenesis, surface markers. Subpopulations of T-lymphocytes and their functions.The role of thymus. Positive and negative selection of T-lymphocytes.B-lymphocytes - ontogenesis, surface markers, function.Primary immune organs and their role in the immune system.Secondary immune organs - structure and function of lymphatic node and spleen.Mucosal immune system.Antigen presenting cells - types, function.Modes of antigen presentation.Th1 based immune reaction.Th2 based immune reaction.Tc based immune reaction.  Immunoglobulins - structure.Immunoglobulins - function.Genetic background of immunoglobulin production.Biological and chemical characteristics of immunoglobulin classes IgG and IgA.Biological and chemical characteristics of immunoglobulin classes IgM, IgD and IgE.Isotype switching. Idiotypes and anti-idiotypes - their role. Immunological memory.Ontogenesis of the immune response.Primary immune response.Secondary immune response. Effector functions of antibodies.       Defense against extracellular pathogens (bacteria and unicellular parasites).Defense against multicellular parasites.Defense against intracellular pathogens (bacteria and unicellular parasites).Anti-viral defense.Possibilities of therapeutic affecting of the immune system - immunomodulation, substitution, suppression.Active and passive immunization.Radioimmunoassay, enzymoimmunoassay - principles, practical use.Laboratory measurement of specific IgE antibodies.Laboratory measurement of autoantibodies.Flow cytometry - principles, practical use.Laboratory methods of assessment of cellular immunity.Laboratory methods of assessment of humoral immunity.Non-organ-specific autoantibodies and their diagnostic significance.Autoantibodies in organ specific autoimmune diseases.Organ-localized autoimmune diseases with non-organ-specific autoantibodies.Autoimmune diseases - pathophysiology, division, laboratory diagnostics, treatment.Examples of systemic autoimmune diseases.Examples of organ-specific autoimmune diseases.Immunosupressive treatment - examples of drugs, indications, risks.Immunodeficiency - characteristics, division, clinical manifestations, treatment.Primary immunodeficiencies - examples.Immunoglobulin replacement therapy.Acquired immunodeficiencies - causes. AIDS.Deficiency of complement components. Hereditary angioedemaTumor immunology - tumor antigens, mechanisms of defense.Immunological examination before transplantation (examination of sensitization, HLA typing).Transplantation immunity - alloimmune reaction.Types of graft rejection.Immunopathological reaction (reaction of hypersensitivity) type II. Principles. Examples of pathological conditions.Immunopathological reaction (reaction of hypersensitivity) type III. Principles. Examples of pathological conditions.Immunopathological reaction (reaction of hypersensitivity) type IV.Principles. Examples of pathological conditions.Immunopathological reaction (reaction of hypersensitivity) type I. Allergens - definition, division and nomenclature.Anaphylaxis - pathophysiology, clinical manifestation, treatment.Diagnostic procedures used in allergology.Treatment of allergic diseases.Examples of diseases based on immunopathological reaction of type I.Primary and secondary antiphospholipide syndrome.Immune mechanisms of male infertility.Immune mechanisms of female infertility.Neuro-endocrine-immunologic interrelationships in gravidity. Principle of materno-foetal tolerance. Rh incompatibility. 

Garant

doc. MUDr. Petr Panzner, CSc.

Vyučující

MUDr. Martin LiškaMgr. Jitka Ochotnádoc. MUDr. Petr Panzner, CSc.