Předmět Klinická biochemie (EA0110126)
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Další informace
Sylabus
Preanalytical influences on laboratory tests.Reference values, methods of their determination.Analytical properties of laboratory methods, quality control.Diagnostic sensitivity and specificity, their relationship, laboratory screening.Basic examination of urine.Non-protein nitrogen substances.Electrophoresis of serum proteins, electrophoretic types.Significance of determination of serum proteins.Na, K, Cl - clinical significance of determination.Ca, P, Mg - clinical significance of determination.Trace elements.Vitamins.Thyroid hormones.Hormones of hypothalamus and pituitary gland.Hormones of adrenal cortex.Metabolic acidosis.Metabolic alkalosis.Respiratory disorders of acid-base balance.Combined disorders of acid-base balance.Determination of oxygen - clinical significance.Metabolic balance.Osmolality - clinical significance.Serum lipids: metabolism and relationship to atherogenesis.Risk factors of atherosclerosis (with exception of lipids).Free radicals, diseases caused by free radicals, antioxidative defence.Laboratory examinations of patients with liver diseases.Laboratory diagnostics of jaundice.Laboratory markers of bone metabolism.Functional tests of kidneys.Laboratory examination of gastrointestinal tract.Laboratory diagnostics of diabetes mellitus.Laboratory control of diabetes mellitus.Laboratory diagnostics of myocardial infarction.Laboratory markers of malignancies (tumour markers).Cytochemical examination of cerebrospinal fluid.Hereditary metabolic diseases - laboratory diagnostics.Laboratory examinations of patients with urinary stones.Laboratory examinations in pregnancy.Peculiarities of laboratory examinations of infants.Basic principles of toxicological examinations.
Literatura
Course Clinical biochemistry, accessible on-line from WWW: https://moodle.mefanet.cz/course/view.php?id=114 (login via CAS), cited on 29.4.2015Beckett, G.J., Walker, S.W., Rae, P., Ashby,P.: Lecture Notes Clinical Biochemistry.8thEdition, Wiley-Blackwell, Oxford, London, Edinburgh etc., 2010, 344 pp. ISBN: 978-1-4051-9305-49thEdition, Wiley-Blackwell, Oxford, London, Edinburgh etc., 2013, 344 pp. ISBN: 9781118272114also accessible via Ebrary (ligin with CAS): http://site.ebrary.com/lib/cuni/detail.action?docID=10748680 [cited on 2.5.2015]
Požadavky
Attening seminars (1 absence allowed) ; successfully passed credit quiz (see literature for direct access to the course, where quiz is).
Garant
Prof.MUDr. Jaroslav Racek, DrSc.