Předmět Immunology (MB150P14E)

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Materiál	Typ	Datum	Počet stažení

Sylabus

In winter semester we will cover the immune system from the perspective of hypotheses:- Immune system basics: conflict of concepts- Immune response: class, polarization and organization- Innate immunity: the danger model & the triggers- Pattern recognition receptors anywhere: adjuvants & inflammation- Antigen processing and presentation: MHC molecules I / II & APCs- Antigen processing and presentation: non-classical MHC and crosspresentation- Introduction to adaptive immunity: Antigen & Immunoreceptors- Molecular mechanisms of TCR / BCR diversity- NK cells & NK receptors: missing-self & alloreactivity- Cytokines, chemokines, migration & signaling- Clinical immunology: Immunopathologies ups&downs, therapies / biotherapies- Immunodeficiencies & tolerance- Recap & questionsIn the following course in summer semester (Immunology - a systems biology view: MB151P101E; without prerequisits) we are going to repeat briefly the essential building blocks at the beginning of each lesson (30 min.) and then cover their interconnection in more detail using big data-driven systems biology approach. Final lessons show the networking at any level in cells (signaling, epigenetic, transcriptional and posttranscriptional levels) and tissues (development, regulation, dynamics and integration with other homeostatic systems).- Development of immune system building blocks (organs, cells, molecules)- Evolution of the immune system (innate and adaptive) - comparative genomics- Receptor diversity generation - immunoreceptor databases and target identification- Signaling pathways and immunosuppression - pathway modeling- Transcription programs and immune cell polarization - microarrays- Metabolic signatures of immune cell types - metabolomics- Heterogeneity of immune cells and target tissues/pathogens - cellomics- Classes of immune response (cytokines, chemokines) - dynamics modeling- Immune-related pathologies and therapies - clinical databases- Immune system organization principles & integration with neural & endocrine systems- Recap & questions

Literatura

Compulsory reading:Lectures on the Moodle course web siteLecture attendance is essential Recommended reading:Basic immunology: entry-level: L. Sompayrac: How the Immune System Works, 4th Edition, John Wiley & Sons, 2012, 152 pages, ISBN-13 978-0470657294mid-level: J. Owen, J. Punt, S. Stranford: Kuby Immunology, 7th Edition, W.H. Freeman, 2013, 691 pages, ISBN-13: 978-1429219198expert-level: K. Murphy: Janeway's Immunobiology (Immunobiology: The Immune System (Janeway)), 8th Edition, Garland Science Publishing 2011, 888 pages, ISBN-13: 978-0815342434Complete 5th Edition is available in search mode at NCBI:http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=imm.TOC&depth=2Fragments of 8th Edition is available at Google Books:http://books.google.cz/books?id=WDMmAgAAQBAJSome chapters in pdf from 8th Edition one can locate on Garlandcience.com via Google under specific keyword searchVideos are available on YouTube Garlandscience channel and directly on Garland web pageMethods in immunology: W. Luttman, K. Bratke, M. Kupper, D. Myrtek: Immunology (The Experimenter), 1st Edition, Academic Press Inc, 2006, 264 pages ISBN-13: 978-0120885442Some chapters are available at Google Books: http://books.google.cz/books?id=nHmCmG7koSkC

Požadavky

A computer test having 20 multiple-choice questions (5 answers each) with 1 hour time limit.Evaluation: - each question is ranked by +5 points in total, if answered correctly - there are one or more correct answers per question possible - each of 5 answers per question is ranked from -2 (incorrect) up to +5 (a single correct answer) pointsClassification:100-94 points = A (excellent - summa cum laude)93-80 = B (very good - insigni cum laude); in Czech classification system = 179-60 points = C (good - magna cum laude); in Czech classification system = 259-47 points = D (quite good - cum laude); in Czech classification system = 346-40 = E (pass - rite); in Czech classification system = 3below 39 = FX, F (fail); in Czech classification system = 4The borderline results (- 2 points) will be retested orally immediately after the test. 

Garant

doc. RNDr. Jan Černý, Ph.D.RNDr. Karel Drbal, Ph.D.

Vyučující

doc. RNDr. Jan Černý, Ph.D.RNDr. Karel Drbal, Ph.D.