Předmět RNA structure and function (MB150P91E)

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Materiál	Typ	Datum	Počet stažení

Sylabus

Sylabus "RNA structure and function"IntroductionRNA polymerase I transcripts ribosomal RNA synthesis and processing, nucleolar structure and function, ribosome structure, and functionRNA polymerase II transcripts regulation of transcription through RNA network, connection between transcription and processing snRNA and snoRNA biogenesis, scaRNAs. telomerase structure and function pre-mRNA processing (capping, splicing, editing, polyA) , alternative splicing, mRNA localization and stability cellular structures involved in RNA metabolismRNA polymerase III transcripts transcription, processing and function of tRNAs, 7SK, SRP, U6, RNA P and MRPCatalytic RNAs ribozymes and riboswitches, spliceosome and ribosome as ribozymesLong non-coding RNAs transcription, processing andfunction of HOTAIR, Air, MALAT1 and 2RNAi synthesis, processing and function of miRNA, piwiRNA, siRNA

Literatura

enes VIII, autor: Benjamin Lewin, Publisher: Prentice Hall | ISBN: 0131238264Molecular Cell Biology. 4th edition. autor: Lodish H, Berk A, Zipursky SL, et al. New York: W. H. Freeman; 2000. ISBN-10: 0-7167-3136-3 (free available on http://www.ncbi.nlm.nih.gov/books/NBK21475/)RNA World 3rd edition, CSHL Press, ISBN 978-087969739-6

Požadavky

Requirements for the exam3-4 topics presented during the course are discussed during the oral exam. At least three days before the exam students have to submit a short (1-2 pages) assay or review about a topic of their choice from RNA biology. The students can choose the language of the assay (English or Czech) and the same language will be used during the oral exam.

Garant

doc. Mgr. David Staněk, Ph.D.