Předmět Immunology - a systems biology view (MB151P103E)

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Materiál	Typ	Datum	Počet stažení

Sylabus

Sylabus: In the summer semester (Immunology - a systems biology view), each lesson will start with a brief summary and repetition of essential building blocks (30 min) and continue with the online resources for data analysis. Using 1-2 examples of recent publications we will demonstrate how the building blocks cooperate and the immune system functions using a big data-driven systems biology approach. Final lessons show the networking at the level of cells (signaling, epigenetic, transcriptional, and posttranscriptional levels) and tissues (development, regulation, dynamics, and integration with other homeostatic systems). - Development of immune system building blocks (organs, cells, molecules) - Evolution of immune system (innate and adaptive) - comparative genomics - Receptor diversity generation - immunoreceptor databases and target identification - Signaling pathways and immunosuppression - pathway modeling - Transcription programs and immune cell polarization - microarrays, transcriptomics - Metabolic signatures of immune cell types - metabolomics - Heterogeneity of immune cells and/or target tissues/pathogens - cellomics - Classes of immune response (cytokines, chemokines) - dynamics modeling - Immune system-related pathologies and therapies - clinical databases - Immune system organization principles & integration with neural & endocrine systems - whole body imaging - Recapitulation & questions

Literatura

Compulsory reading:Lectures on the Moodle course web site include:primary publications,data examples andrecommended SW to be usedLecture attendance is essential - we will focus on interactive method using real data and will discuss the outputsRecommended reading:Basic immunology:L. Sompayrac: How the Immune System Works, 4th Edition, John Wiley & Sons, 2012, 152 pages, ISBN-13 978-0470657294Expert-level immunology:K. Murphy: Janeway's Immunobiology (Immunobiology: The Immune System (Janeway)), 8th Edition, Garland Science Publishing 2011, 888 pages, ISBN-13: 978-0815342434Complete 5th Edition is available in search mode at NCBI: http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=imm.TOC&depth=2Fragments of 8th Edition is available at Google Books: http://books.google.cz/books?id=WDMmAgAAQBAJSome chapters in pdf from 8th Edition one can locate on Garlandcience.com via Google under specific keyword searchVideos are available on YouTube Garlandscience channel and directly on Garland web pageSystems immunology:No textbook in Systems immunology is currently availableprimary papers and review articles:Enabling a systems biology approach to immunology: focus on innate immunity. http://www.ncbi.nlm.nih.gov/pubmed/19428301R.N. Germain et al.: Systems biology in immunology: a computational modeling perspective. http://www.ncbi.nlm.nih.gov/pubmed/21219182B.A.Kidd et al.:Unifying immunology with informatics and multiscale biology. http://www.ncbi.nlm.nih.gov/pubmed/2444856An interactive reference framework for modeling a dynamic immune system http://www.ncbi.nlm.nih.gov/pubmed/26160952The genetic architecture of the human immune system: a bioresource for autoimmunity and disease pathogenesis. http://www.ncbi.nlm.nih.gov/pubmed/25772697

Požadavky

A computer test having 20 multiple-choice questions (5 answers each) with 1 hour time limit.Evaluation: - each question is ranked by +5 points in total, if answered correctly - there are one or more correct answers per question possible - each of 5 answers per question is ranked from -2 (incorrect) up to +5 (a single correct answer) pointsClassification:100-94 points = A (excellent - summa cum laude)93-80 = B (very good - insigni cum laude); in Czech classification system = 179-60 points = C (good - magna cum laude); in Czech classification system = 259-47 points = D (quite good - cum laude); in Czech classification system = 346-40 = E (pass - rite); in Czech classification system = 3below 39 = FX, F (fail); in Czech classification system = 4The borderline results (- 2 points) will be retested orally immediately after the test.

Garant

RNDr. Karel Drbal, Ph.D.