Předmět Medical Chemistry (LCH / VAA11)

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Materiál	Typ	Datum	Počet stažení

Obsah

Atoms, molecules, bonds. Chemical equilibrium. Dispersion systems: solutions, colligative properties of solutions, osmotic pressure. Dispersion systems: colloids, interphases, adsorption. Electrolyte solutions: acids and bases, strong and weak electrolytes, ionization of water, pH, equilibrium constants Kw, Ka, Kb, Ksp, hydrolysis. Electrolyte solutions: ampholytes, titration curves, solubility, slightly soluble compounds. Life and energy, principles of bioenergetics. Reaction rate, enzyme kinetics. Reduction and oxidation, galvanic cells, reduction potentials. Structure of organic molecules Reactivity of organic molecules. Selected organic and bioorganic compounds. Selected organic and bioorganic compounds, polymers. Heterocyclic compounds. Biologically important reactions of organic molecules. Aminoacids and peptides. Saccharides. Lipids. Bioelements, coordination compounds. Toxicity of elements and compounds. Reactive oxygen species, lipoper oxidation, antioxidants, major environmental pollutants. Chemical nomenclature, revision. Chemical calculations - concentration, ionic strength. Chemical calculations - osmotic pressure, solubility, solubility constant. Chemical calculations: equilibria, weak electrolytes, buffers. Chemical calculations: reduction and oxidation rections, energy. Organic chemistry I. Organic chemistry II. Organic chemistry III, bioelements. Test.

Získané způsobilosti

The student will be able to evaluate how basic types of inorganic and organic compounds react either with each other or with other biological macromolecules, to predict whether the given compound will/will not adversely affect living systems, and estimate the usefulness of the compound for modulation of metabolic pathways in human body.

Literatura

Dvořáčková, S. a kol. Calculations in medical chemistry. Olomouc: Palacký University, 2007. ISBN 978-80-244-1775-2.Táborská, E. et al. Medical Chemistry I. General and inorganic chemistry. Brno: Masaryk University, 2006. ISBN 80-210-4091-2.Dostál, J. Medical Chemistry II. Bioorganic chemistry. Brno: Masaryk University, 2006. ISBN 80-210-4128-5.Táborská, E., Dostál, J. Overview of chemistry. Brno: Masaryk University, 2010. ISBN 978-80-210-5193-5.Chang, R., Overby, J. General Chemistry: The Essential Concepts. McGraw-Hill, 2010. ISBN 978-0077354718.Hein, M., Best, L.R., Pattison, S., Arena, S. Introduction to General, Organic, and Biochemistry. 8th Edition. Wiley, 2004. ISBN 0-471-45196-7.

Požadavky

100% attendance, measurement protocols completed

Garant

doc. Mgr. Martin Modrianský, Ph.D.

Vyučující

Mgr. Jana Franková, Ph.D.doc. Mgr. Martin Modrianský, Ph.D.Mgr. Jiří Vrba, Ph.D.Mgr. Jana Franková, Ph.D.doc. Mgr. Martin Modrianský, Ph.D.Mgr. Jiří Vrba, Ph.D.