Předmět Pathological Physiology 2 (PFY / ZAA12)

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Materiál	Typ	Datum	Počet stažení

Obsah

Introduction. Basic concepts in pathophysiology. Normal, abnormal, healthy, ill. Syndromes, symptoms, objective tests. Alternative medicine. General mechanisms of diseases. 1. Disturbances of homeostasis. Course and outcomes of diseases. General mechanisms of diseases. 2. Disturbances of intercellular and intracellular signalling cascades. Inflammation. Mechanisms. Symptoms. Fever. Pathophysiology of immunity. The major disturbances of immunity. The major symptoms that can be observed on skin and mucosa. Acute circulatory failure. 1. A review. Syncope. Sudden death. Acute circulatory events in stomatology. Acute circulatory failure. 2. Shock. Phases, development. Principles of prevention and therapy. Acute and chronic cardiac failure. Chronic circulatory failure. The major forms. Etiology, genesis, principles of treatment. Ischemic heard disease as a civilisation disorder. Acute myocardial infarction. Etiology, development, diagnosis, principles of prevention and therapy. Hypertension as a civilisation disorder. Etiology, genesis, principles of prevention and therapy. The major diseases of vessels and peripheral circulation. Endothelial dysfunction. Atherogenesis, atherosclerosis. Vessel disability in major systemic diseases. Disturbances of haemocoagulation. Coagulopathies. Bleeding. Disturbances of fibrinolysis. Importance in stomatology. Thrombophilia as a civilisation disorder. The major diseases of blood cells. Diseases of erythrocytes, leucocytes and thrombocytes. Symptoms observable on skin and mucosis. The major respiratory disturbances. Obstructive diseases, emphysema, restrictive diseases. Respiratory failure. Respiratory distress syndromes. Principles of prevention and treatment.

Získané způsobilosti

The subject introduces a student into a complex dynamic role and mutual interplay of both external (environmental) and internal (genetic) factors in the origin and development of diseases. Based on the definition of risk factors, the subject lays emphasis on the key role of the civilization risk factors and analyses the major civilization disorders as a consequence of the conflict between environmental cues and inherited dispositions. In particular, the student gets knowledge about etiopathogenesis of diseases and learns the basis for practical therapeutic and preventive measures.

Literatura

Hall, J. E. Guyton and Hall Textbook of Medical Physiology. Saunders, 2010. ISBN 978-1416045748.Braunwald E et al. (2008). Harrison s Principles of Internal Medicine. Longo, D., Fauci, A., Kasper, D., Hauser, S., Jameson, J., Loscalzo, J. Harrison´s Principles of Internal Medicine. McGraw-Hill Professional, 2011. ISBN 978-0071748896.http://portal.lf1.cuni.cz. http://portal.med.muni.cz/Weatherall, D. J., Ledingham, J. G. G., Warrell, D. A. Oxford Textbook of Medicine (3 Volume Set). Oxford University Press, 1996. ISBN 978-0192621405.Hulín, I. Pathophysiology. Slovak Academic Press, 1997. ISBN 8085665905.McCance, K. L., Huether, S. E., Brashers, V. L., & Rote, N. S. (2014). Pathophysiology: the biologic basis for disease in adults and children. St. Louis, Mo: Elsevier. Guyton, A. C. (2011). Textbook of Medical Physiology. Philadelphia. www.mefanet.cz

Požadavky

Successful attendance in 85% of the compulsory practicals (letter of apology necessary in the case of absence), passing tests and/or oral interviews covering the topics of all the compulsory exercises.

Garant

prof. MUDr. Martin Petřek, CSc.

Vyučující

prof. MUDr. Martin Petřek, CSc.MUDr. Iveta Poljaková, Ph.D.MUDr. Dagmar Riegrová, CSc.prof. MUDr. Martin Petřek, CSc.MUDr. Dagmar Riegrová, CSc.