Předmět Bioactive Natural Compounds (S342009)
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Další informace
Sylabus
History of the subject, Basic terms. Pharmacognosy and chemosystematics. Cellular and molecular targets of biological activity. Polysacharides: Fibers, gums, mucillages and pectins - plants: Acacia sp., Astragalus gummifer, Ceratonia siliqua, Psilium sp., Agar agarSpecifically active proteins: Enzymes, lectins, protein sweeteners - plants: Carica papaya., Canavalia ensiformis, Ricinus communis, Abrus precatorius, Thaumatococcus sp.Alkaloids I: Generalities, taxonomical occurance, protoalkaloids. Alkaloids II. Selected types of alkaloids and their biological activities - plants: Atropa belladona, Erythroxylon cocca, Nicotiana sp., Areca catechu, Conium maculatum,Papaver somniferum, Cataranthus roseus, Strychnos nux-vomica, Physostigma venenosum Alkaloids III. Ergot alkaloids, pseudoalkaloids, purine alkaloids. - plants: Claviceps purpurea, Aconitum sp. Veratrum sp., Coffea arabica, Camelia sinensis, Theobroma cacao, Ilex paraguayensisGlycosylation, Specific examples of bioactive glycosides: Cardiac glycosides, saponins, glucosinolates, cyanogenic glycosides. - plants: Digitalis sp, Drimia maritima, Glycyrrhiza glabra, Aesculus hippocastanum, Hedera helix, Brassica sp., Manihot esculenta.Phenolics I: Generalities. Phenolic acids and their esters, coumarins. - plants: Myroxylon balsamum, Rosmarinus officinalis, Salix sp., Meliotus officinalis, Heracleum sp. Phenolics II: Flavonoids and lignans. Phytoestrogens. - plants: -Silybum marianum, Fagopyrum esculentum, Glycine max., Trifolium sp, Linum usitatissimumPhenolics III. Tannins. Quinones and floroglucinols. - plants: -Quercus sp., Juglans regia, Lawsonia inermis, Cassia sp., Rhamnus frangula, Humulus lupulus, Cannabis sp.Terpenoids I: Monoterpenes and essential oils. Toxic diterpenes. - plants: -Lavandula sp., Mentha sp., Thymus sp, Carum carvi, Citrus aurantium, Taxus sp., Croton sp., Daphne mezerumTerpenoids II: Triterpenoids, steroids and carotenoids. Vitamin A and retinoids. - plants: -Betula sp., Cucurbita sp., Capsicum annuum, Crocus sp.,Excursion (Botany Garden)
Literatura
Jean Bruneton: Pharmacognosy. Lavoisier Publishing Inc., Paris, 1999, reprint 2001.ISBN: 1-898298-63-72. Paul M. Dewick: Medicinal Natural Products � A Biosynthetic Approach. John Wiley& Sons Ltd., Chichester, England. 2002. ISBN 0471 49641 33. Joanne Barnes, Linda A. Anderson, J. David Philipson: Herbal Medicines.Pharmaceutical Press, London, UK 2007. ISBN 978 0 85369 623 0
Garant
Lapčík Oldřich prof. Dr. RNDr.